Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas

Molecular profiles of oxyphilic and chief cell parathyroid adenoma

CONTEXT Parathyroid adenomas may be composed of chief cells (conventional or water-clear), oxyphilic cells or a mixture of both cells. The molecular background is rarely studied. OBJECTIVE To molecularly characterize parathyroid adenomas of different cell type composition. DESIGN Chief and oxyphilic cell adenomas were compared in a cohort of 664 sporadic cases. Extensive analyses of parathy...

Increased protein kinase A type Iα regulatory subunit expression in parathyroid gland adenomas of patients with primary hyperparathyroidism.

Protein kinase A (PKA) regulatory subunit type Iα (RIα) is a major regulatory subunit that functions as an inhibitor of PKA kinase activity. We have previously demonstrated that elevated RIα expression is associated with diffuse-to-nodular transformation of hyperplasia in parathyroid glands of renal hyperparathyroidism. The aim of the current study was to determine whether or not RIα expression...

Parathyroid Glands The four parathyroid glands, derived from pharyngeal pouches III and IV, are found on the surface of the thyroid gland and consist of chief cells and oxyphilic

Morphological Evaluation of Parathyroid Adenomas and Immunohistochemical Analysis of PCnA and Ki-67 Proliferation Markers Paratiroid Adenomlarında Morfolojik Değerlendirme ve PCNA ile Ki-67 Proliferasyon Belirleyicileri Bakımından İmmünohistokimyasal İnceleme

Objective: Parathyroid adenomas are the most common cause of primary hyperparathyroidism. Biological studies have shown that parathyroid adenomas are monoclonal proliferations. Up to date, five cell types have been identified in normal parathyroid tissues; chief cells, vacuolated chief cells, dark chief cells, oxyphil cells and transitional oxyphil cells. Most parathyroid adenomas are predomina...

P167: Effect of Mitochondrial Mutation on Depression and Anxiety

Mitochondria are membrane-enclosed organelle found in most eukaryotic cells, which known as power house in cells. This organelle transforms energy into forms that are usable by the cell. The most common psychiatric disorders such as depression and anxiety can be linked to mitochondrial disorders. Furthermore, mutations of mitochondrial or nuclear DNA (mtDNA and nDNA, respectively) have been lin...